Peroxisomes in Biology and Medicine by K. Gorgas (auth.), Professor Dr. H. Dariush Fahimi,

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By K. Gorgas (auth.), Professor Dr. H. Dariush Fahimi, Professor Dr. Helmut Sies (eds.)

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Quantitation of the Uomunoelectron microscopic data was in excellent agreement with the biochemical results. FOllowing cholestyramine treatment there was an 8 fold increase in the density of gold particles per peroxisome and about a 3 fold increase in the labeling of the ER. W. determination of peroxisomal HMG-CoA reductase indicated 97 kD and 55 kD polypeptides. We also have data that suggests the peroxisomal HMG-CoA reductase activity can be regulated by a phosphorylation-dephosphorylation mechanism, similar to that mediated by ~ reductase-kinase in the microsames.

3. Separation of peroxisanes fran other cell organelles. 25 g/ml) of a light mitochondrial (lambda) fraction fran cholestyramine treated animals. The ordinate, relative concentration, is derived by dividing the actual concentration of the enzyme in a particular fraction by the concentration of the enzyme that '-Duld be observed if the enzyme '-Duld be hanogenously distributed throughout the gradient. The abscissa is normalized cumultive volume (the total volume was 32 ml); the area of each graph is thus 1.

W. determination of peroxisomal HMG-CoA reductase indicated 97 kD and 55 kD polypeptides. We also have data that suggests the peroxisomal HMG-CoA reductase activity can be regulated by a phosphorylation-dephosphorylation mechanism, similar to that mediated by ~ reductase-kinase in the microsames. 1he major portion of this ~rk has been published (1). INI'ROIXJCrICN 1he key regulatory enzyme of cholesterol, dolichol, and isopentenyl aienosine biosynthesis, 3-h}droxy-3-methylglutaryl coenzyme A reductase (HMG-CoA reductase) is a 97 kD transmembrane glycoprotein which was believed until recently to reside exclusively in the endoplasmic reticulum of mammalian cells (2,3, ) • However, a recent publication showed that the enzyme in liver cells is present not only in the endoplasmic reticulum but also within peroxisames (4).

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