Pediatric Otolaryngology by Christopher J. Hartnick

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By Christopher J. Hartnick

Sataloff's complete Textbook of Otolaryngology: Head & Neck surgical procedure - Pediatric Otolaryngology is a part of a multi-volume textbook masking simple and medical technological know-how around the whole box of otolaryngology. Volumes within the set comprise; otology, neurotology and skull-based surgical procedure; rhinology, hypersensitivity and immunology; facial plastic and reconstructive surgical procedure; laryngology and head and neck surgical procedure. the total set is improved via over 5000 complete color photographs and illustrations, spanning approximately 6000 pages, entire with a accomplished index on DVD. Edited via Robert T Sataloff from Drexel college university of drugs, Philadelphia, this quantity contains contributions from the world over acknowledged specialists in otolaryngology, making sure authoritative content material all through. Sataloff's accomplished Textbook of Otolaryngology: Head & Neck surgical procedure - Pediatric Otolaryngology is an crucial, in-depth consultant to the sector for all otolaryngology practitioners. Key issues * Textbook of paediatric otolaryngology, a part of six-volume set masking the full box of otolaryngology * Volumes contain otology/neurotology, rhinology, cosmetic surgery, laryngology, head and neck surgical procedure, and paediatric otolaryngology * Over 5000 complete color pictures and illustrations throughout six volumes * Edited through Robert T Sataloff, with contributions from across the world regarded otolaryngology specialists

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2003;23(11):4395-400. 70. Fire A, Xu S, Montgomery MK, et al. Potent and spe­ cific genetic interference by double-stranded RNA in Caenorhabditis elegans. Nature. 1998;391:806-11. 71. Ambros V. The functions of animal microRNAs. Nature. 2004;431:350-55. 72. Vickers TA, Koo S, Bennett CF, et al. Efficient reduc­ tion of target RNAs by small interfering RNA and RNase H-dependent antisense agents: a comparative analysis. J Biol Chem. 2003;278:7108-18. 73. Mukherjea D, Jajoo S, Kaur T, et al. Transtympanic adminis­ tration of short interfering (si)RNA for the NOX3 iso- form of NADPH oxidase protects against cisplatin-induced hearing loss in the rat.

2003;60(5-6): 423-33. 35. Kondoh H, Kamachi Y. SOX-partner code for cell specifica­ tion: regulatory target selection and underlying molecular mechanisms. Int J Biochem Cell Biol. 2009;42(3):391-9. 36. Kiernan AE, Pelling AL, Leung KK, et al. Sox2 is required for sensory organ development in the mammalian inner ear. Nature. 2005;434(7036):1031-5. 37. Shi F, Kempfle JS, Edge AS. Wnt-responsive Lgr5-expressing stem cells are hair cell progenitors in the cochlea. J Neurosci. 2012;32(28):9639-48. 38.

16 A subset of supporting cells with stem cell-like properties was 16 Section 1: Pediatric Otology A B C Figs. 3A to C: Inner ear stem cell (sphere) types. Cochlear stem cells harvested from the neonatal organ of Corti (A). Neural stem cells harvested from the spiral ganglion (B). Vestibular stem cell isolated from the utricle (C). identified: third row of Deiters’ cells, inner pillar, and inner border cells, as well as the greater epithelial ridge. 37,44 Wnt signaling plays a role in proliferation and cell fate specification in embryonic development and in stem cells and is highly conserved throughout species.

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