Nucleic Acids and Molecular Biology by G. J. Thomas Jr., A. H.-J. Wang (auth.), Professor Dr. Fritz

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By G. J. Thomas Jr., A. H.-J. Wang (auth.), Professor Dr. Fritz Eckstein, Dr. David M. J. Lilley (eds.)

Molecular biology has continuously been a self-discipline of swift improvement. regardless of this, we're almost immediately experiencing a interval of unheard of proliferation of knowledge in nucleic acid reviews and molecular biology. those components are in detail interwoven, in order that each one impacts the opposite to their mutual gain. The speedy development in info results in ever-increasing specialization, in order that it turns into more and more tricky for a scientist to maintain abreast of advancements in all of the a number of points of the sphere, even if an up to date wisdom of the sphere as an entire is extremely fascinating. With this history in brain we current the sequence Nucleic Acids and Molecular Biology. It contains concentrated assessment articles by means of lively researchers who file at the latest advancements of their parts of specific interest.

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Wiley, New York, pp 233-309 Thomas GJ, Jr (1987) Raman spectra and the conformations of biological macromolecules. In: Spiro TG (ed) Biological applications of Raman spectroscopy, vol 1. Wiley, New York, pp 135-201 Thomas GJ, Jr, Agard DA (1984) Quantitative analysis of nucleic acids, proteins and viruses by Raman band deconvolution. Biophys J 46 :763 -768 Thomas GJ, Jr, Benevides JM (1985) An A-helix structure for poly(dA-dT) "poly (dAdT). Biopolymers 24: 1101-1105 Thomas GJ, Jr, Hartman KA (1973) Estimation of RNA secondary structure from Raman scattering by phosphate group vibrations.

A proposed double-helical model for the solution structure of poly (r A) . poly(dT), based upon equilibrium and dynamic Raman results (Benevides and Thomas 1988). 1ntranucleotide hydrogen bonding of the adenine 8 C-H donor to the 5'0 acceptor is shown for the central three residues of the rA strand 24 GJ. Thomas, Jr. -J. Wang down the helix axis shows the close positioning of the rA . dT base pairs to the axis, similar to that occurring in more conventional B-DNA structures despite the C3' endo sugars of the rA strand.

Samples were divided, linearized with A: Xbal; B: BstEII and end labelled by backfilling with reverse transcriptase. Electrophoresis on a 7% denaturing acrylamide gel. Dominant cleavage sites on the polypyrimidine strand are at TpC linkages while ApG linkages are more sensitive on the polypurine strand. Although the d(TC)n:d(GA)n repeat ends at the points indicated, a weak but regular pattern of nuclease cleavage can be followed beyond the ends of the insert A B linkages. As in the case of the pTC45 insert the dG residues of the 3' portion of the polypurine strand are partially protected against attack by dimethylsulphate.

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