Nature (Vol. 435, No. 7043, 9 June 2005)

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The outer faces of the pairs of sheets are hydrated and more distant from each other, implying that this less intimate interaction could be a crystal contact rather than a feature of the fibrillar state. The suggestion that the fundamental structural unit of a fibril could be just a pair of rather flat sheets is consistent with conclusions from studies of amyloid fibrils of several proteins, including insulin, by cryo-electron microscopy10 — so adding further support to the supposition that the inherent fibrillar interactions have been captured in the crystalline molecular array.

Buee, M. et al. Mol. Plant Microbe Interact. 13, 693–698 (2000). 7. Lerouge, P. et al. Nature 344, 781–784 (1990). 8. Cook, C. E. et al. Science 154, 1189–1190 (1966). 9. Yoder, J. I. Curr. Opin. Plant Biol. 4, 359–365 (2001). 10. , Takeuchi, Y. & Yokota, T. Physiol. Planta 112, 25–30 (2001). 11. Kosuta, S. et al. Plant Physiol. 131, 952–962 (2003). 12. Hijri, M. & Sanders, I. R. Nature 433, 160–163 (2005). COMPUTATIONAL SCIENCE Can get satisfaction Carla P. Gomes and Bart Selman The sheer complexity of some computational problems means they will probably never be solved, despite the ever-increasing resources available.

Heart-rending emotion of Dark think, he shied away from specifically repre- Elegies. However, the maturity of these pieces, senting relativity in the piece, alluding only in choreographed by Anthony Tudor in the the title to that theory’s central tenet of a con- 1930s, perhaps highlighted a few rough edges stant speed of light. Brownian motion, on the in Constant Speed. The physics is there if you look — but don’t other hand, is a concept easily reflected in the movements and configuration of the dancers.

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