Multiple Sclerosis Therapeutics, Third Edition by Jeffrey A. Cohen, Richard A. Rudick

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By Jeffrey A. Cohen, Richard A. Rudick

Since the book of the former variation of this quantity, there was big development in a few parts of a number of sclerosis (MS) study. even supposing immunosuppressive remedies stay built and subtle, extra specific immunomodulatory cures are surfacing as we research extra approximately how the immune process works in future health and disease.

Multiple Sclerosis Therapeutics, 3rd Edition

presents a entire evaluation of medical trial technique and healing modalities in MS. This variation displays present realizing of the pathophysiology of the ailment and comprises well known and rising remedies.

Topics include:

  • Biomarkers in MS
  • Pharmacogenomics
  • Emerging healing modalities equivalent to natalizumab, T-cell-based and B-cell-based remedies, cytokine/chemokine-based cures, statins, and 4-aminopyridine
  • Neuroprotection
  • The use of OCT and MRI to steer illness therapy

Within the subsequent numerous years, we'll start to become aware of the application and the constraints of stem cells within the remedy of MS. it really is most likely that the following version of this text will contain medical trial facts that overview early makes an attempt at apprehensive approach regeneration in MS. until eventually that point happens, this quantity continues to be a necessary source for neurologists and a person excited by the therapy of MS.

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Additional info for Multiple Sclerosis Therapeutics, Third Edition

Example text

Ischemia or intrinsic abnormalities of myelin), none has been confirmed. It was hoped that long-term follow-up of patients treated with natalizumab might provide a test of whether potent, non-cytotoxic suppression of CNS inflammation initiated early in the disease would prevent the subsequent clinical and imaging manifestations of progressive disease. That ‘experiment’ has been discontinued, and the question of whether inflammation is the primary cause of CNS damage or a response to it remains unresolved.

Third, as mentioned, the distinction between clinical disease categories is not precise, and the reliability of classifying patients into these categories has never been confirmed. In all likelihood, different clinical trials that appear to include the same patient population actually contain different admixtures of patients. This point is well-illustrated by the European and North American trials of interferon β-1b in SPMS, in which two trials with very similar entry criteria enrolled different patient populations that yielded different results with the same therapeutic agent (Chapter 23).

First, excessively narrow entry criteria can impede recruitment. Second, it may not be clear whether the results of a trial enrolling a highly selected cohort of patients can be extrapolated to other groups of MS patients. Third, as mentioned, the distinction between clinical disease categories is not precise, and the reliability of classifying patients into these categories has never been confirmed. In all likelihood, different clinical trials that appear to include the same patient population actually contain different admixtures of patients.

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