Modelling in Molecular Biology by Daniel A. Beard, Hong Qian, James B. Bassingthwaighte

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By Daniel A. Beard, Hong Qian, James B. Bassingthwaighte (auth.), Gabriel Ciobanu, Grzegorz Rozenberg (eds.)

This quantity contains papers involved in types and strategies utilized in fixing a few basic difficulties of biosciences. They signify a large spectrum of numerous principles and tendencies. specifically, they mirror the certainly interdisciplinary nature of analysis on modelling in molecular biology – the foundation, rules and methods offered during this quantity come from arithmetic, laptop technological know-how, data, chemistry and biology.

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1995). Linkage and the limits to natural selection. Genetics 140, 821–841. 2. Campos, P. R. A. and J. F. Fontanari (1998). Finite-size scaling of the quasispecies model. Phys. Rev. E 58, 2664–2667. 3. Charlesworth, B. (1994). The effect of background selection against deleterious mutations on weakly selected, linked variants. Genet. Res. Camb. 63, 213–227. 4. Cuevas, J. , S. F. Elena, and A. Moya (2002). Molecular basis of adaptive convergence in experimental populations of RNA viruses. Genetics 162, 533– 542.

Robertson (1966). The effect of linkage on the limits to artificial selection. Genet. Res. 8, 269–294. A. Campos, Christoph Adami, and Claus O. Wilke 20. Johnson, T. and N. H. Barton (2002). The effect of deleterious alleles on adaptation in asexual organisms. Genetics 162, 395–411. 21. Kimura, M. (1962). On the probability of fixation of mutant genes in a population. Genetics 47, 713–719. 22. Kimura, M. (1968). Evolutionary rate at the molecular level. Nature 217, 624– 626. 23. Kimura, M. and T. Ohta (1969).

The decrease occurs for those Δt for which the two beneficial mutants coexist for several generations in the population. Fixation of mutant 1 in this regime occurs only when mutant 1 reaches fixation so quickly that mutant 2 has not had time to build up momentum. Otherwise, most likely mutant 1 will be displaced by mutant 2 before reaching fixation. For mutant 2, the time to fixation T2 is shorter for negative Δt than for positive Δt. A. Campos, Christoph Adami, and Claus O. 1 Fig. 4. 5, Δt = 100, N = 1000).

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