Mitochondria: Structure, Biogenesis and Transducing by H. Tedeschi

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By H. Tedeschi

In the earlier few years, the physique of experimental paintings at the constitution, functionality and meeting approaches of mitochondria has increased swiftly. nobody individual can think himself or herself thoroughly answerable for the burgeoning literature with out owning severe omissions or blind spots. within the current monograph i've got tried a severe review of the literature. i feel that the typical thread of unmarried authorship outweighs the shortcomings of 1 individual featuring many disparate viewpo,ints. it truly is my desire that the tip product represents a entire and coordinated evaluate of the subject material to the current date. even though the majority of this monograph used to be accomplished by means of October 1974, i've got made a few makes an attempt to replace a number of of the sections at later occasions. Albany, N. Y. , November 1975 H. TEDESCHI Contents A. constitution of Mitochondria 1. normal association . a) traditional skinny part Electron Microscopy b) damaging Staining suggestions . three c) Freeze-Cleavage . . . . . . . four 2. particular association and Inclusions 10 a) Prismatic or bizarre Cristae 10 b) Filaments and Tubules . . eleven c) Amorphous Inclusions 12 d) Intramitochondrial Granules 12 e) DNA Containing Fibers 14 three. Topography of the Mitochondrial Transducing structures 15 B. The meeting of Mitochondria 18 1. Mitochondrial DNA and Its Genetic function 19 2. Transcription of the Mitochondrial DNA . 28 a) mRNA . . . . . . . . . . . . . . 30 b) The equipment for Transcription and Translation 32 c) Turnover of Mitochondrial RNA 36 three. Protein Synthesis . . . . . . . . 37 a) Mitochondrial Protein Synthesis and Its features 37 b) position of Mitochondrial Protein Synthesis . .

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1965, MARTIN and BOSMANN 1971, ITO et al. 1974 b). Most but not all of them seem to be associated with the external mitochondrial membrane and the intramembrane space (ITo et al. 1974 a). The function or site of origin of these proteins is not known. The enzyme mannosyltransferase has been found associated with the inner mitochondrial membrane (MORELIS et al. 1974), suggesting that at least some of the processing of the glycoproteins could be taking place in the mitochondria. b) Role of Mitochondrial Protein Synthesis It is now recognized that mitochondria are assembled by a complex interaction between two protein synthesizing systems.

1950, EPHRUSSI 1953, RAUT 1953, WAGNER and MITCHELL 1955, PITTMAN 1959, PITTMAN et ai. 1960, SHERMAN and SLONIMSKI 1964). The genes coding for the structure of iso-1-cytochrome c (the major cytochrome c of wild-type yeast) are chromosomal (SHERMAN et ai. 1965, 1966). Its synthesis has been shown to be governed by at least six distinct genes. Only one of these is the gene coding for the structure of the apoprotein (SHERMAN 1966). This suggests a complex pattern for either regulation or assembly.

1971, SCHMITT 1970). Both ribosomal subunits are required for the synthesis of polyphenylalanine directed by poly (U) (GRIVELL et al. 1971). Recent studies with Neurospora indicate that the 73 S ribosomes are probably not the functioning ribosomes which probably sediment at 80 S. In contrast to the 80 S ribosomes, the 73 S ribosomes are not active in forming polysomes (AGSTERIBBE et al. 1974). A complete characterization has been carried out for the ribosomes of the mitochondria of the yeast Candida utilis (VIGNAIS et ai.

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