By Ephraim Yavin, Annette Brand (auth.), Mark P. Mattson (eds.)
Lipid rafts-discrete areas in mobile membranes which are wealthy in ldl cholesterol and sphingolipids-are rising not just as pivotal command and keep an eye on facilities for mobile signaling tactics, but in addition as significant to a big selection of human ailments, together with immune issues, diabetes, heart problems, and Alzheimer's illness. In Membrane Microdomain Signaling: Lipid Rafts in Biology and drugs, multidisciplinary specialists provide state of the art studies of our present realizing of those membrane microdomains and their physiological and pathological roles. right here, readers will become aware of how lipid rafts switch in cells over the years and the way they reply to numerous environmental signs, how ldl cholesterol modulates the signaling functionality of lipid rafts, and the way lipid rafts, the extracellular matrix, and the cellphone cytoskeleton structurally engage. additionally defined are the position of lipid rafts in studying, reminiscence, and melanoma, and as portals for endocytic uptake of an anticancer- and apoptotic alkyl-lysophospholipid. The authors additionally current rising facts that lipid rafts play severe roles in signaling pathways and the law of synaptic functionality within the frightened procedure, and that changes in lipid raft metabolism are implicated within the pathogenesis of neurodegenerative issues. in addition they describe innovations for the isolation of lipid rafts, the research of the lipid and protein elements of lipid rafts, the imaging of lipid rafts in dwelling cells, and the research of sign transduction in lipid rafts.
entire and insightful, Membrane Microdomain Signaling: Lipid Rafts in Biology and medication bargains researchers a multidisciplinary evaluation of the most recent simple, translational, and medical learn that can provide to remodel our figuring out microdomain signaling mechanisms.
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Additional info for Membrane Microdomain Signaling: Lipid Rafts in Biology and Medicine
And Matkó J. (2004) Rafting MHC-II domains in the APC (presynaptic) membrane and the thresholds for T-cell activation and immunological synapse formation. Immunol. Lett. 92, 117–124. Harder T. (2003) Formation of functional cell membrane domains: the interplay of lipid- and protein-mediated interactions. Philos. Trans. Soc. , B, Biol. Sci. 358, 863–868. , Scheiffele P. , and Simons K. (1998) Lipid domain structure of the plasma membrane revealed by patching of membrane components. J. Cell Biol.
8, 566–574. Lanzavecchia A. and Sallusto F. (2001) Antigen decoding by T lymphocytes: from synapses to fate determination. Nature Immunol. 2, 487–92. Lawrence J. , Saslowsky D. , Edwardson J. , and Henderson R. M. (2003) Real time analysis of the effect of cholesterol on lipid raft behavior using atomic force microscopy. Biophys. J. 84, 1827–1832. Lee S. J. , Groves J. , Dustin M. , and Chakraborty A. K. (2002) The synapse assembly model. Trends Immunol. 23, 500–502. Lin J. and Weiss A. (2000) T cell receptor signaling.
Nature 375, 148–151. van Blitterswijk W. , van der Luit A. , Veldman R. , and Borst J. (2003) Ceramide: second messenger or modulator of membrane structure and dynamics? Biochem. J. 369, 199–211. van Meer G. (2002) The different hues of lipid rafts. Science 296, 855–857. Varma R. and Mayor S. (1998) GPI-anchored proteins are organized in submicron domains at the cell surface. Nature 394, 798–801. , Ibrahim S. , et al. (2000) Cholesterol-dependent clustering of IL-2Ralpha and its colocalization with HLA and CD48 on T lymphoma cells suggest their functional association with lipid rafts.