Lung Development Biological and Clinical Perspectives. by Philip Farrell

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By Philip Farrell

Lung improvement: organic and scientific views: Biochemistry and body structure, quantity I, offers a complete and multidisciplinary treatise in regards to surfactant-related concerns in lung maturation. regardless of the planned emphasis on biochemistry during this quantity, the purpose is to put this knowledge within the viewpoint of anatomy, body structure, and medical perinatology.
The ebook is equipped into 4 elements. half I deals a quick old point of view by means of reviewing the chronology of medical and simple advances. half II then establishes a body of clinical reference by way of reviewing the morphology and cytology of lung improvement and the body structure of pulmonary surfactant. levels of improvement and adaptations within the maturation procedure are emphasised, whereas cautions to the biochemist are provided with appreciate to interpretation of experimental facts. half III presents an advent to lung biochemistry. half IV bargains with the developmental biochemistry of lung phospholipid metabolism; the featured compound is the principal surfactant part, phosphatidylcholine (PC). a focus for dialogue issues regulatory mechanisms working to manage the construction of saturated notebook in the course of overdue gestational improvement of the fetal lung.

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The Study of Lung Development Fig. 3 . Mucus cell from rat bronchus. The cytoplasm is dark, in contrast to the pale-staining mucous granules that fill the apex of the cell and appear to coalesce. At the lower right the well developed endoplasmic reticulum is evident. Bar = 1 μ π ι . and pattern of glycoprotein stained in their granules. Mucous cells vary in their staining reactions both between species and within the same species. In some species including man, neutral, sulfated, and carboxylated glycoconjugate all occur (98, 113).

Kotas, R. V . , and Avery, Μ. E. (1980). The influence of sex on fetal rabbit lung maturation and on the response to glucocorticoid. Am. Rev. Respir. Dis. 121, 377. 19. Kotas, R. V . , Farrell, P. M . , Ulane, R. , and Chez, R. A. (1977). Fetal rhesus monkey lung development: Lobar differences and discordances between stability and distensibility. J. Appl. Physiol. 4 3 , 92. 20. Landing, Β. H. (1979). Congenital malformation and genetic disorders of the respiratory tract. Am. Rev. Respir. Dis. 120, 151.

These studies have also suggested that the osmiophilic lamellar bodies are the intracellular deposits of surfactant. In essence, they may be viewed as secretory granules of unique morphology and composition. The synthesis of surfactant phospholipid has been traced by sequen­ tial electron microscopic analysis after administration of a radioisotopic precur­ sor; the precursor has usually been H-choline, which in brief periods of time labels phosphatidylcholine almost exclusively (9). Such studies revealed a se­ quence typical for exocrine cells: rapid uptake of precursor from capillaries —»—> transfer to endoplasmic reticulum —>—> synthesis of phospholipid ->—> transfer via Golgi apparatus and perhaps special proteins to the osmiophilic lamellar bodies for "packaging" —»—> secretion into the alveolar space.

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