[Journal] Nature Chemical Biology. Volume 5. Number 4

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67, 573–579 (2007). 13. M. & Fujii, N. Bioorg. Med. Chem. Lett. 18, 946–949 (2008). 14. Tonikian, R. et al. PLoS Biol. 6, e239 (2008). 15. A. et al. J. Biol. Chem. 281, 22312–22320 (2006). 16. J. et al. J. Biol. Chem. 278, 7645–7654 (2003). 17. H. T. Curr. Biol. 13, 680–685 (2003). 18. , Chassaing, G. & Prochiantz, A. Trends Cell Biol. 8, 84–87 (1998). 19. J. J. Biophotonics Int. 11, 36–42 (2004). 219 ARTICLES Identification of a chemical probe for NAADP by virtual screening Edmund Naylor1,4, Abdelilah Arredouani1,4, Sridhar R Vasudevan1,4, Alexander M Lewis1, Raman Parkesh1, Akiko Mizote2, Daniel Rosen1, Justyn M Thomas1, Minoru Izumi2, A Ganesan3, Antony Galione1 & Grant C Churchill1 Research into the biological role of the Ca2+-releasing second messenger NAADP (nicotinic acid adenine dinucleotide phosphate) has been hampered by a lack of chemical probes.

Chem. 16, 4670–4675 (2008). 96. Li, B. et al. Highly efficient endoglycosidase-catalyzed synthesis of glycopeptides using oligosaccharide oxazolines as donor substrates. J. Am. Chem. Soc. 127, 9692–9693 (2005). 97. , Hauser, S. X. A highly efficient chemoenzymatic approach toward glycoprotein synthesis. Org. Lett. 8, 3081–3084 (2006). 98. F. et al. Synthesis of N-glycan oxazolines: donors for endohexosaminidase catalysed glycosylation. Carbohydr. Res. 341, 1574–1596 (2006). 99. D. et al. Enhanced glycosylation with mutants of endohexosaminidase A (Endo A).

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