By R. C. Kennedy (auth.), Professor Dr. Hilary Koprowski, Professor Dr. Fritz Melchers (eds.)
The variety of antigen-binding constructions of antibody molecules is so immense that each achieveable antigen should be certain by way of an antibody molecule in the immune approach. this can be precise even for the antigen binding websites of antibodies known as idiotypes, that are certain by means of complementary bind ing websites of alternative antibodies known as anti-idiotypes. hence, anti-idiotypes are structural homologues of antigens. those idiotypic-anti-idiotypic interactions represent a community in the immune approach. on the grounds that one lymphocyte produces just one kind of antibody molecule, this community is actually a community of cells. we predict that the community is sensible: the looks of antigen will disturb the equilibrium of the community on the aspect the place it competes with the anti idiotypic lymphocyte for binding to the idiotypic lympho cyte. it's been identified for particularly your time that anti idiotypic antibody can be utilized to major the immune method for reminiscence to an antigen that it hasn't ever noticeable. This phe nomenon is now being explored for attainable use in immuni zation opposed to viruses, micro organism, parasites and tumors in addition to for the modulation of autoimmunity. the power of anti-idiotypes to imitate, either antigenically and serve as best friend, the corresponding biologically energetic molecules visible by way of an idiotypic antibody was once first confirmed for the hormone insulin and is now being saw in lots of different structures. The papers assembled during this quantity· deliver the reader to the leading edge of the capability functional applica tions of the community thought of the immune system.
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The variety of antigen-binding buildings of antibody molecules is so great that each plausible antigen might be certain by means of an antibody molecule in the immune method. this can be actual even for the antigen binding websites of antibodies referred to as idiotypes, that are sure by means of complementary bind ing websites of alternative antibodies referred to as anti-idiotypes.
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Additional resources for Images of Biologically Active Structures in the Immune System: Their Use in Biology and Medicine
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