Images of Biologically Active Structures in the Immune by R. C. Kennedy (auth.), Professor Dr. Hilary Koprowski,

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By R. C. Kennedy (auth.), Professor Dr. Hilary Koprowski, Professor Dr. Fritz Melchers (eds.)

The variety of antigen-binding constructions of antibody molecules is so immense that each achieveable antigen should be certain by way of an antibody molecule in the immune approach. this can be precise even for the antigen binding websites of antibodies known as idiotypes, that are certain by means of complementary bind­ ing websites of alternative antibodies known as anti-idiotypes. hence, anti-idiotypes are structural homologues of antigens. those idiotypic-anti-idiotypic interactions represent a community in the immune approach. on the grounds that one lymphocyte produces just one kind of antibody molecule, this community is actually a community of cells. we predict that the community is sensible: the looks of antigen will disturb the equilibrium of the community on the aspect the place it competes with the anti­ idiotypic lymphocyte for binding to the idiotypic lympho­ cyte. it's been identified for particularly your time that anti­ idiotypic antibody can be utilized to major the immune method for reminiscence to an antigen that it hasn't ever noticeable. This phe­ nomenon is now being explored for attainable use in immuni­ zation opposed to viruses, micro organism, parasites and tumors in addition to for the modulation of autoimmunity. the power of anti-idiotypes to imitate, either antigenically and serve as­ best friend, the corresponding biologically energetic molecules visible by way of an idiotypic antibody was once first confirmed for the hormone insulin and is now being saw in lots of different structures. The papers assembled during this quantity· deliver the reader to the leading edge of the capability functional applica­ tions of the community thought of the immune system.

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Images of Biologically Active Structures in the Immune System: Their Use in Biology and Medicine

The variety of antigen-binding buildings of antibody molecules is so great that each plausible antigen might be certain by means of an antibody molecule in the immune method. this can be actual even for the antigen binding websites of antibodies referred to as idiotypes, that are sure by means of complementary bind­ ing websites of alternative antibodies referred to as anti-idiotypes.

Additional resources for Images of Biologically Active Structures in the Immune System: Their Use in Biology and Medicine

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Eur J Immunol 4: 296-302 Epstein SL, Masakowski VR, Sharrow SO, Bluestone JA, Ozato K, Sachs DH (1982) Idiotypes of anti-lA antibodies. n. Effects of in vivo treatment with xenogeneic anti-idiotype. J. Reagan Ert! HC, Finberg RW (1984) Sendai virus specific T cell clones: induction of cytolytic T cells by an anti-idiotypic antibody directed against a helper T cell clone. Proc Nat! Acad Sci USA 81:2850-2854 Frischnecht H, Binz H, Wigzell H (1978) Induction of specific transplantation i=une reactions using anti-idiotypic antibodies.

N. Effects of in vivo treatment with xenogeneic anti-idiotype. J. Reagan Ert! HC, Finberg RW (1984) Sendai virus specific T cell clones: induction of cytolytic T cells by an anti-idiotypic antibody directed against a helper T cell clone. Proc Nat! Acad Sci USA 81:2850-2854 Frischnecht H, Binz H, Wigzell H (1978) Induction of specific transplantation i=une reactions using anti-idiotypic antibodies. J Exp Med 147: 500-514 Greene MI (1985) Anti-idiotypic immunoglobulin as a vaccine for viral immunity.

Plenum, New York Coutinho A, Forni L, Holmberg D , Ivars F, Vaz N (1984) From an antigen-centered, clonal perspective of immune responses to an organism-centered, network perspective of autonomous activity in a self-referential immune system. Immunol Rev 79: 151 Emini EA, Jameson BA, Lewis AJ, Larsen GR, Wimmer E (1982) Poliovirus neutralization epitopes: analysis and localization with monoclonal antibodies. J Virol 43 : 997 Ert! HCJ, Finberg RW (1984) Sehdai virus-specific T-cell clones: induction of cytolytic T cells by an anti-idiotypic antibody directed against a helper T-cell clone.

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