Hallucinogenic Drugs and Their Psychotherapeutic Use by R. A. Sandison and Alexander Walk, Editors Richard Crocket

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By R. A. Sandison and Alexander Walk, Editors Richard Crocket

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A. Somatic and Physiological Effects The action on the neurovegetative system is very marked. Mydriasis is almost constant. Changes in the pulse rate are usual; bradycardia is found in two-thirds of the normal subjects and in one half of the mental patients; in the others the rate is increased or varies. Instability of blood pressure is frequently seen, but isolated hypertension and hypotension are about equally common. 70 per cent. of cases show increased tendon reflexes. Normal subjects present subjective complaints more often than do mental patients.

PICHOT a n d T . OF PSILOCYBINE LEMPÉRIÈRE PSILOCYBINE is one of the active principles of the hallucinogenic fungi of Mexico. It was first isolated from Psilocybe mexicana (Heim) in 1958 by Hofmann, who subsequently effected its synthesis. It is the first phosphorylated indole compound to have been found in nature, but this phosphorylation of the indole nucleus probably plays no part in its psychodysleptic activity; thus, psilocine, which is derived from psilocybine by dephosphorylation, has the same psychodysleptic properties.

Int. Journ. Soc. , 1 9 5 3 , 3 , 3. , Wien. Med. , 1 9 5 8 , 1 0 8 , 1 0 9 1 . PECK, T. , The Use of LSD in Psychotherapy, The Josiah Macy Jr. Foundation, p. 181, New York, 1960. THE THERAPEUTIC By J. DELAY, IMPLICATIONS P. PICHOT a n d T . OF PSILOCYBINE LEMPÉRIÈRE PSILOCYBINE is one of the active principles of the hallucinogenic fungi of Mexico. It was first isolated from Psilocybe mexicana (Heim) in 1958 by Hofmann, who subsequently effected its synthesis. It is the first phosphorylated indole compound to have been found in nature, but this phosphorylation of the indole nucleus probably plays no part in its psychodysleptic activity; thus, psilocine, which is derived from psilocybine by dephosphorylation, has the same psychodysleptic properties.

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