Dendritic cell interactions with bacteria by Maria Rescigno

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By Maria Rescigno

Rising facts means that dendritic cells play an enormous function within the orchestration of the immune reaction to micro organism. This quantity introduces the reader to the complicated international of dendritic cells and describes how the intimate interaction among dendritic cells, micro organism and the surroundings dictates both the induction of immunity or tolerance to the encountered microorganisms. It discusses how this may let organisms to tolerate worthy micro organism and to react opposed to pathogens, in addition to the suggestions pathogenic micro organism have developed to flee dendritic mobile patrolling. professional members speak about every little thing from bacterial catch and popularity to their killing, processing and the induction of adaptive immunity. specific concentration is at the tissue context within which micro organism are dealt with by way of dendritic cells and on attainable defects therein, that could possibly bring about power an infection or irritation. Graduate scholars and researchers will locate this a useful review of present dendritic cellphone biology learn.

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Rev. , 3, 582–90. , Li, C. L. and Shortman, K. (1993). Thymic dendritic cells and T cells develop simultaneously in the thymus from a common precursor population. Nature, 362, 761–3. , Pin, J. , Briere, F. and Trinchieri, G. (2003). Mouse strain differences in plasmacytoid dendritic cell frequency and function revealed by a novel monoclonal antibody. J. , 171, 6466–77. , Colonna, M. and Kalinke, U. (2002). Virus-induced interferon alpha production by a dendritic cell subset in the absence of feedback signaling in vivo.

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White thick arrows indicate antigen transfer. Double arrows indicate Tcell direct priming; grey thick arrows indicate Tcell crosspriming. Abbreviations: i-DC, immature DC; LC, Langerhans cell; m-DC, mature DC. (For a processes; black broken arrows represent migration processes; grey broken arrows represent hypothetical differentiation or migration processes. 1. Integrated model of the development and function of the mouse DC system. e. inner part of the splenic white pulp, deep cortex of the lymph nodes, and interfollicular regions of the lymphoid aggregates of the intestinal tract).

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