Chemotherapy for Gynecological Neoplasms: Current Therapy by R Angioli; et al

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By R Angioli; et al

Files contemporary advances in gynecological oncology, belly and pelvic surgical procedure, and molecular biology during this reference for physicians and surgeons. The e-book starts off with fabric on simple ideas of chemotherapy, with emphasis at the mechanisms of motion of assorted medicines, and on immunotherapy, gene remedy, and pharmacogenomics. basic medical points of chemotherapy are mentioned, similar to supportive Read more...

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Anticancer Res 1996; 16:3845–3848. Mechanism of Chemosensitivity and Resistance 3. 4. 5. 6. 7. 8. 9. 10. 11. 12. 13. 14. 15. 16. 17. 18. 19. 20. 21. 22. 23. 24. 25. 26. 27. 33 Ashkenazi A, Dixit VM. Death receptors: signaling and modulation. Science 1998; 281: 1305–1308. O’Gorman DM, Cotter TG. Molecular signals in anti-apoptotic survival pathways. Leukemia 2001; 15:21–34. O’Connor R. Survival factors and apoptosis. Adv Biochem Eng Biotechnol 1998; 62: 137–166. Coukos G, Rubin SC. Chemotherapy resistance in ovarian cancer: new molecular perspectives.

Cytokeratin Cytokeratin is an intermediate filament-type protein. The combination of cytokeratin 8 and 18 is a major cytoplasmic component of epithelial-derived tumors. Studies have shown that the intrinsic MDR drug resistance phenotype is partially attributable to the expression of cytokeratin 8 and 18. Mitoxantrone has been shown to modify cytokeratin. Cytokeratin-dependent drug resistance (C-MDR), however, is not associated with the cell’s ability to assemble the cytokeratin monomers into intermediate filament networks.

Clinical studies of reversal of drug resistance based on glutathione. Chem Biol Interact 1998; 111–112, 213–224. Martin SJ, Green DR, Cotter TG. Dicing with death: dissecting the components of the apoptosis machinery. Trends Biochem Sci 1994; 19:26–30. Surbone A, Gilewski TA, Norton L. Cytokinetics. In: Holland JF, Bast RC, Morton DL, eds. Cancer Medicine. 4th ed. Baltimore: Williams & Wilkins, 1997:769–799. Mechanism of Chemosensitivity and Resistance 37 83. Perez RP, Hamilton TC, Ozols RF. Resistance to alkylating agents and cisplatin: insights from ovarian carcinoma model systems.

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