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Extra info for Cell Biology and Membrane Transport Processes
Similarly, during mammalian development, there are often circumstances where one cell induces a differentiative event in a neighboring cell, or a tissue induces developmental changes that are confined to a single layer of overlying epithelial cells. Some of the agents that appear to be responsible for such events, for example IL-la and IL-lp and acidic and basic fibroblast growth factors, do not appear to be secreted by the classical secretory pathway (Kuchler and Thorner, 1990; Kuchler and Thorner, 1992aj, as discussed in detail in a previous section.
M. (1990). Use of recombinant p-glycoprotein fragments to produce antibodies to the multidrug transporter. Biochern. Biophys. Res. Commun. 166,180-186. , Cumer, S. , Haugland, R. , Gottesman, M. , and Willingham, M. C. (1990). Activity of the multidrug transporter results in alkalinization of the cytosol: Measurement of cytosolic pH by microinjection of a pH-sensitive dye. J . Histochem. Cytochem. 38, 685-690. Valverde, M. , Sepulveda, F. , Gill, D. , Hyde, S. , and Higgins, C . F. (1992). Volume-regulated chloride channels associated with the human multidrug resistance P-glycoprotein.
The responses induced result in a massive rearrangement of the cytoskeleton leading to asymmetric growth and formation of a projection. The tip of this elongated projection is the actual site of conjugation where the two haploid cell types fuse to form a zygote. We found that the level of Ste6p undergoes a dramatic change when yeast cells are exposed to mating pheromone. , 1989). Hence, in response to receipt of an a-factor signal, MATa cells will be provoked into emitting a greatly elevated a-factor signal.