By Dennis Krikler (auth.), Professor Dr. M. Schlepper, Dr. B. Olsson (eds.)
Asked to prepare a global assembly on Propafenone (Ryt monorm) we needed to query ourselves, no matter if to just accept this provide simply as physicians or in our ability as chairmen of the research crew on arrhythmias and intracardiac electrography of the ecu Society of Cardiology. Considerung the "pros and contras" and good acutely aware that you'll simply be considered as "product promoter" we, however, decide to arrange the Symposion in organization with the examine workforce. We felt justified to take action for a few purposes: Arrhyth mias and their remedy in addition to the instruments to become aware of the 1st and to regulate the latter are good in the scope of the research team. a world symposion supplied the chance to have the "state of the artwork" in arrhythmias and antiarrhythmic therapy completely reviewed by way of the world over well known investigators, hence serving a tutorial objective. in addition it used to be the goal and objective of the assembly to have what's identified a few rather new drug provided in a serious demeanour and to indicate what's no longer identified, yet may be identified. it truly is in that context the shows of the unfastened consultation will be judged. To the cautious reader it's going to turn into obvious that a lot which used to be now not acknowledged, should be learn "between the lines".
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Extra resources for Cardiac Arrhythmias: Diagnosis Prognosis Therapy
Propafenone in Ventricular Arrhythmias At the ventricular level, the two effects of P are useful whenever an adrenergic factor is present. This is not the case for idiopathic ventricular premature beats when they are isolated, but doublets, salvos, and runs of ventricular tachycardia are mostly present during the day or after exercise. In general, this applies to any complex ventricular arrhythmia occurring in the context of a myocardial disease, or whenever the characteristics of the ventricular arrhythmia are distinctive because of their occurrence during effort, the left ventricular origin of the extrasystoles, or the irregularity and the polymorphism of the tachycardias (Coumel et al.
The patient died in September 1981, but the terminal tracing (right) shows that the ventricular tachycardia was still being controlled at that time 30 P. -F. Leclercq h14 QRS/min 15 16 17 18 20 19 21 22 23 o 2 I 180 120 60 a. -. ~ ~, .... , .... ~ J'o ""- r'" ..... 30 o . H~~r. ,. Fig. 7. Duration of action ofpropafenone (case no. 32). m. in this relatively resistant ventricular tachycardia. , at which time the first run of ventricular tachycardia (lower tracing) is detected from the maximal heart rate curve.
Results Prevalence of Late Potentials in Various Groups of Patients (Table 1) In 27 "normal" subjects (12 medical students or physicians of the hospital, 15 patients with no evidence of coronary artery disease or left ventricular dysfunction during heart catheterization), no late potentials were detected. In all cases there was a smooth transition from the QRS complex to the STsegment in the high-amplitude recording (Fig. 1). In group II, 69 patients with previously documented ventricular tachycardia and/or ventricular fibrillation in whom these arrhythmias could be reproducibly initiated by programmed ventricular stimulation were studied.