By Gunnar Steineck MD (auth.), Michael J. Droller MD (eds.)
The expanding prevalence of bladder melanoma within the usa and around the globe bargains a superb chance to raised comprehend the biology of this melanoma and to use clinically appropriate examine within the consultation room. In Bladder melanoma: present prognosis and remedy, Michael J. Droller and a panel of skilled clinicians and researchers deliver their powerful heritage in medical examine to endure at the evaluation and administration of this crucial illness. Their finished dialogue summarizes the state of the art in analysis and remedy, according to the most recent knowing of bladder cancer's epidemiology, carcinogenesis, genetics, and tumor markers. themes of specific curiosity contain the position of genetics and molecular biology in comparing bladder melanoma clinically, the evaluate of the result of systemic therapy in complicated disorder, the present prestige of tumor markers in bladder melanoma, and the capacity for additional research in their applicability.
Insightful and evidenced-based, Bladder melanoma: present analysis and remedy presents energetic clinicians and medical investigators with not just a serious survey of the swiftly increasing learn within the zone, but additionally a state of the art instructional on cutting-edge optimum review and therapy of bladder cancer.
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Extra resources for Bladder Cancer: Current Diagnosis and Treatment
Case RAM, Hosker ME, Mcdonald DB, Pearson JT. Tumours of the urinary bladder in workers engaged in the manufacture and use of certain dyestuff intermediates in the Brittish chemical industry. The role of aniline, benzidine, alpha-naphthylamine and beta-naphthylamine. Br J Ind Med 1954; 11: 75–104. 22. Hicks RM, Wright R, Wakefield JSJ. The induction of rat bladder cancer by 2-naphthylamine. Br J Cancer 1982; 46: 646–661. 23. He MRJA, Mason T, Mettlin C, Vogler WJ, Maygarden S, Liu E. P53 mutations in bladder tumors from arylamine-exposed workers.
The pendulum swung several times in the ensuing years. In the 1950s, Melicow, and Kaplan clearly demonstrated associated areas of dysplasia and pre-neoplasia in the urothelium intervening between sites of frank neoplasia (80,81). However subsequent work by McDonald showed that urothelial malignancies could be implanted into and grow on sites of urothelial trauma even given relatively crude immunosuppression and understanding of transplant rejection in that era (84). These observations were later expanded on by Soloway and the specific mechanisms involved in tumor implantation delineated by See (85,88,89).
It is now believed that there may be six or more independent mutational events (11,12) necessary for carcinogenesis. Furthermore, 30 Theodorescu and See Fig. 1. Proposed pathway for bladder tumor development derived from clinical observation. Note that the superficial and invasive pathways are distinct, with divergence early in the process of tumorigenesis. (From Jones PA, Droller MJ. Pathways of development and progression in bladder cancer: new correlations between clinical observations and molecular mechanisms.