Biomarkers: In Medicine, Drug Discovery, and Environmental by Vishal S. Vaidya, Joseph V. Bonventre

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By Vishal S. Vaidya, Joseph V. Bonventre

This booklet presents an creation to the sector of biomarkers, how they've been and will be used, and the way diversified techniques can be utilized to spot, signify, and display screen biomarkers. The booklet has chapters on subject matters together with HIV, melanoma, Parkinson’s, vascular harm, environmental publicity. A following part discusses the applied sciences (diagnostics and assays) to notice biomarkers and authors have emphasised the preclinical and scientific manifestation of the injury/disease strategy.

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A. Application of Genomic Biomarkers to Predict Increased Lung Tumor Incidence in 2-Year Rodent Cancer Bioassays. Toxicol. Sci. 2007;97:55-64. , and Nilsson, K. C , et al. Predictive Models of Hepatotoxicity Using Gene Expression Data from Primary Rat Hepatocytes. Xenobiotica. 2006;36:1122-1139. , and Barros, S. Toxicogenomics Strategies for Predicting Drug Toxicity. Pharmacogenomics. 2006;7:1003-1016. , et al. Prediction of Drug-Induced Liver Injury in Humans by Using In Vitro Methods: The Case of Ximelagatran.

C. Transcriptional Profiling for Understanding the Basis of Mitochondrial Involvement in Disease and Toxicity Using the Mitochondria-Specific MitoChip. Mutat. Res. 2007;616:210-212. 24 BIOMARKERS 55. 56. 57. 58. 59. 60. 61. 62. 63. 64. 65. 66. 67. 68. 69. 70. 71. 72. , Desai, V. , and Kale, V. , et al. Underlying Mitochondrial Dysfunction Triggers Flutamide-Induced Oxidative Liver Injury in a Mouse Model of Idiosyncratic Drug Toxicity. Toxicol. Appl. Pharmacol. 2009. Desai, V. , and Delongchamp, R.

Daniels, K. , Xu, Z. , and Mendrick, D. L. Tissue and Species Distribution of the Glutathione Pathway Transcriptome. Xenobiotica. 2006;36:1081-1121. Mattes, W. B. Cross-Species Comparative Toxicogenomics as an Aid to Safety Assessment. Expert Opin. Drug Metab. Toxicol. 2006;2:859-874. Baken, K. , Pennings, J. , and Jonker, M. , et al. Overlapping Gene Expression Profiles of Model Compounds Provide Opportunities for Immunotoxicity Screening. Toxicol. Appl. Pharmacol. 2008;226:46-59. DiBlasio-Smith, E.

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