Biology of the Lysosome by John B. Lloyd (auth.), John B. Lloyd, Robert W. Mason (eds.)

Posted by

By John B. Lloyd (auth.), John B. Lloyd, Robert W. Mason (eds.)

From a preview of a prior volume:
`The heterogeneity of topics...is very bold, and the result's, total, profitable end result of the prime quality of the person contributions...highly recommended.'
Amercian Scientist.

`Well written and timely...of curiosity to all these taken with the examine of this organelle and for these drawn to the clinical and genetic facets of lysosomal disorders...recommended.'
Journal of clinical Genetics

Show description

Read or Download Biology of the Lysosome PDF

Best biology books

Becker's World of the Cell (8th Edition)

“Because we take pleasure in interacting with biology below- grads and imagine that they need to have biology textbooks which are sincerely written, make the subject material correct to the reader, and support them take pleasure in not just how a lot we already find out about biology—cell biology, in our case—but additionally how even more continues to be investi- gated and chanced on.

Molecular Biology of Long Non-coding RNAs

​Long non-coding RNAs (lnc)RNAs have emerged as a brand new paradigm in epigenetic law of the genome. millions of lncRNAs were pointed out and saw in a variety of organisms. in contrast to mRNA, lncRNA haven't any protein-coding capability. ​So, whereas their functionality isn't really fullyyt transparent, they could function key organizers of protein complexes that let for better order regulatory occasions.

Images of Biologically Active Structures in the Immune System: Their Use in Biology and Medicine

The range of antigen-binding buildings of antibody molecules is so titanic that each plausible antigen will be certain via an antibody molecule in the immune method. this is often real even for the antigen binding websites of antibodies known as idiotypes, that are certain by way of complementary bind­ ing websites of alternative antibodies known as anti-idiotypes.

Extra info for Biology of the Lysosome

Example text

The cellular localization of the oligosaccharide sulfotransferase and the possible role of sulfate groups in hydrolase sorting have not been investigated. A key step in targeting of newly synthesized soluble hydrolases to the lysosome is the formation of phosphomannosyl residues on high-mannose oligosaccharides. The initial transfer of GlcNac-l-phosphate to mannose, forming al,6-linked branches of the carbohydrate chains, may occur in the intermediate compartment (Hauri and Schweizer, 1992). A second phosphorylation can occur on mannoses, forming al,3-linked branches, after the removal of terminal mannose residues by an a-mannosidase in the cis-Golgi.

Although phosphorylation of arylsulfatase B in vitro causes changes in the enzyme activity toward an artificial substrate, it remains to be determined whether protein phosphorylation of lysosomal enzymes is a common modification and related to enzymatic regulation in vivo. , 1995a). The cysteine residue is converted into a 2-amino-3-oxopropionic acid residue that is required to generate catalytically active sulfatases, and this modification is lacking in arylsulfatase A and B from cells of patients with multiple sulfatase deficiency.

1992). , 1992). , 1990). 1 and Chapter 3 of this volume). For the two MPRs it has been demonstrated that deletion of the carboxyterminal four or five amino acids of the cytoplasmic domains containing dileucine motifs leads to a decrease in sorting efficiency of lysosomal enzymes (Johnson and Kornfeld, 1992a,b). Since the recycling of these mutant receptors from the plasma membrane to the Golgi was unaffected, the authors suggested that additional signals for efficient sorting may overlap with the internalization sequences.

Download PDF sample

Rated 4.93 of 5 – based on 27 votes