By Kursad Turksen
This entire quantity explores services, pathologies, and functions of stem cells in terms of the niches during which they boost. Ten chapters disguise the topic intensive, from a historic point of view via signaling, hormonal keep watch over, quiescence, biomimetics, epigenetics, engineering suggestions for emulating, tumorigenesis and extra. The bankruptcy authors characterize a huge variety of foreign services and perspectives.
This installment of the preferred Stem cellphone Biology and Regenerative medication sequence gives you authoritative, foreign views in this quickly transforming into box. Biology of Stem phone Niche is a perfect complementary quantity to Tissue-Specific Stem cellphone area of interest and grownup Stem Cells, moment variation and may be valuable to clinicians and researchers operating with stem cells in addition to to postgraduate trainees who're learning them.
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Extra resources for Biology in Stem Cell Niche
Tiedt R, Schomber T, Hao-Shen H, Skoda RC. Pf4-Cre transgenic mice allow the generation of lineage-restricted gene knockouts for studying megakaryocyte and platelet function in vivo. Blood. 2007;109(4):1503–6. 86. Tzeng YS, Li H, Kang YL, Chen WC, Cheng WC, Lai DM. Loss of Cxcl12/Sdf-1 in adult mice decreases the quiescent state of hematopoietic stem/progenitor cells and alters the pattern of hematopoietic regeneration after myelosuppression. Blood. 2011;117(2):429–39. 87. Umemoto T, Yamato M, Ishihara J, Shiratsuchi Y, Utsumi M, Morita Y, et al.
Existing evidence suggesting that adult stem cells remain in a quiescent state, or that they slowly progress through the cell cycle, came from experiments in which corneal tissue was exposed to long labeling periods with DNA precursors. After a label-dilution period, label-retaining cells (LRC) exclusively found at the limbal basal layer, were considered corneal stem cells . In addition, the use of the exclusion of vital DNA binding dye Hoechst 33342 to identify the Side Population (SP)  showed that limbal epithelial stem cells express high levels of the ATP binding cassette transporter protein ABCG2 and its corresponding mRNA [75–78], which could be playing a role in protection of stem cells .
45. Leon-Rico D, Aldea M, Sanchez R, Segovia JC, Weiss LA, Hidalgo A, et al. Reduced expression of CD18 leads to the in vivo expansion of hematopoietic stem cells in mouse bone marrow. Stem Cells. 2014;6(10). 46. Lin KK, Rossi L, Boles NC, Hall BE, George TC, Goodell MA. CD81 is essential for the re-entry of hematopoietic stem cells to quiescence following stress-induced proliferation via deactivation of the Akt pathway. PLoS Biol. 2011;9(9):e1001148. J. Childress et al. 47. Liu F, Poursine-Laurent J, Link DC.