Biology and Pathology of Astrocyte-Neuron Interactions by Leif Hertz (auth.), Sergey Fedoroff, Bernhard H. J.

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By Leif Hertz (auth.), Sergey Fedoroff, Bernhard H. J. Juurlink, Ronald Doucette (eds.)

This quantity is made of papers awarded on the moment foreign Altschul Symposium: Biology and Pathology of Astrocyte-Neuron Interactions. The symposium was once held in Saskatoon, Canada on the collage of Saskatchewn in might, 1992 in reminiscence of Rudolf Altschul, a graduate of the collage of Prague and a pioneer within the fields of the biology of the vascular and frightened structures. Dr. Altschul used to be Professor and Head of the dept of Anatomy on the college of Saskatchewan from 1955 to 1963. The Altschul Symposia have been made attainable by way of an endowment left via Anni Altschul and through different contributions. The symposia are held biennially. one of many maximum demanding situations for latest scientists is to discover the mechanisms of mind functionality. even though mobile anatomy of the worried procedure has already been good defined and certainly used to be delineated by means of the start of the century, experimental research of the functionality of the mind is comparatively fresh. The framework of the mind is made from stellate cells, the astrocytes, that are interconnected via their techniques, therefore proposing a meshwork by which the neurons ship their axons, followed by way of oligodendrocytes. Microglia are allotted during the brain.

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A study of cation binding, J. Anat. 108:419-432. N. , Chapman and Hall, London. , 1990, The agrin hypothesis, Cold Spring Harbor Symp. Quant. Biol. 55:407-418. , 1990, Synthesis and transport of agrin-like molecules in motor neurons, J. Exp. Res. 153:1-14. , 1990, Sodium channel expression detected with antibody 7493 in A2B5+ and A2B5- astrocytes from rat optic nerve in vitro, Glia 3:358-368. , 1992, Sodium channel expression in optic nerve astrocytes chronically-deprived of axonal contact, Glia, in press.

A. Black, H. R. J. Sims, C. Hildebrand, and others; I am grateful to these colleagues for helpful discussions. Work in the author's laboratory has been supported in part by the Medical Research Service, Department of Veterans Mfairs, and by grants from the National Institutes of Health and the National Multiple Sclerosis Society. , 1991, Components of astrocytic extracellular matrix are regulated by contact with axons, Ann. NY Acad. Sci. 633:566-570. , 1985, Localization ofNa/K ATPase in multiple cell types of murine nervous system with antibodies raised against the enzyme from kidney.

1991a,b; Sontheimer and Waxman 1992). , hippocampal astrocytes) appear to be pluripotent in terms of Na+ channel synthesis, expressing a "neuronal" type of Na+ current under some conditions (Sontheimer et al. 1991a). The question, of whether astrocytic Na+ channels are an artifact of culture, was answered when immuno-ultrastructural methods for Na+ channel localization were developed. Immunoelectron microscopic studies, using polyclonal antibodies directed against rat brain Na+ channels (Elmer et al.

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