By Trygve O. Tollefsbol (auth.), Trygve O. Tollefsbol (eds.)
Biological getting older: tools and Protocols investigates some of the approaches which are laid low with the age of an organism. a number of new instruments for the research of organic getting older were brought lately, and this quantity presents equipment and protocols for those new suggestions as well as its assurance of proven strategies. The editors have rigorously chosen merely these issues which are thought of mainstays of the sphere or are displaying promise in revolutionizing this particularly new technology. the 3 major components of concentration during this state-of-the-art compendium of organic getting older study are: equipment which are uncomplicated to realizing the elemental mechanisms of mobile getting older; concepts used to interfere within the getting older technique; and techniques to studying the numerous molecular tactics of organic getting older. Researchers looking new know-how and methods will locate this quantity of super gain as they circulation in the direction of new instructions within the fascinating and increasing box of organic getting older.
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Extra resources for Biological Aging: Methods and Protocols
And Wahl, G. M. (1994) DNA damage triggers a prolonged p53-dependent G1 arrest and long-term induction of Cip1 in normal human fibroblasts. Genes Dev. 8, 2540–2551. 18. Robles, S. J. and Adami, G. R. (1998) Agents that cause DNA double strand breaks lead to p16INK4a enrichment and the premature senescence of normal fibroblasts. Oncogene 16, 1113–1123. 19. Lombard, D. , Chua, K. , and Alt, F. W. (2005) DNA repair, genome stability, and aging. Cell 120, 497–512. 20. , and Lotze, C. (1995) Mild hyperoxia shortens telomeres and inhibits proliferation of fibroblasts: a model for senescence?
30. , et al. (2003) Control of the replicative life span of human fibroblasts by p16 and the polycomb protein Bmi-1. Mol. Cell. Biol. 23, 389–401. 03_Dimri 1/25/07 12:58 PM Page 32 04_von Zglnicki 1/25/07 1:11 PM Page 33 4 Methods for Cell Sorting of Young and Senescent Cells João F. Passos and Thomas von Zglinicki Summary Cellular senescence, the ultimate and irreversible loss of replicative capacity of cells in primary culture, has been a popular model for studying the aging process. However, the replicative life span of human fibroblasts is heterogeneous even in clonal populations, with the fraction of senescent cells increasing at each population doubling, rather than all cells entering senescence simultaneously.
17. , Linke, S. , and Wahl, G. M. (1994) DNA damage triggers a prolonged p53-dependent G1 arrest and long-term induction of Cip1 in normal human fibroblasts. Genes Dev. 8, 2540–2551. 18. Robles, S. J. and Adami, G. R. (1998) Agents that cause DNA double strand breaks lead to p16INK4a enrichment and the premature senescence of normal fibroblasts. Oncogene 16, 1113–1123. 19. Lombard, D. , Chua, K. , and Alt, F. W. (2005) DNA repair, genome stability, and aging. Cell 120, 497–512. 20. , and Lotze, C.